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KMID : 0363420090230030233
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Journal of Korean Oriental Pediatrics
2009 Volume.23 No. 3 p.233 ~ p.240
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The Effects of Okwada on the Lung Fibrosis Mouse Model
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Lee Hai-Ja
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Abstract
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Objectives: To evaluate that Okwada affected which factors for treatment of lung fibrosis.
Methods: Bleomycin induced lung fibrosis model made in mice. After Okwada lyophilized, power sample obtained and melt in distilled water. Okwada solution administered mice through oral route on 21 days after bleomycin instillation and this procedure performed once a day for 7 days. We divided by three groups; normal (control), bleomycin induced lung fibrosis without treatment (experimental), bleomycin induced lung fibrosis with treatment (treatment). On six weeks after bleomycin instillation, mice sacrificed and removed lung. Weperformed Western blot analysis for TGF-beta, phosphodiesterase 5A, interleukin (4,5,13) and compared therapeutic effects of Okwada.
Results: On western blot analysis, all normal and experimental mice detected TGF-beta, phosphodiesterase 5A, interleukin 4,5,13. The amount of band of TGF-beta, phosphodiesterase 5A, interleukin 5 in experimental and treatment group was similar. However, interleukin 4,13 of treatment group decreased compared with experimental group.
Conclusions: Okwada would be effected the lung fibrosis through suppression of interleukin 4,13.
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KEYWORD
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Okwada, fibrosis
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